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Multiple Sclerosis Research Group

Hsuan Pu Chen, Ph.D.

Postdoctoral Fellow

Hsuan Chen, Ph.D.

Department of Neurology
University of California San Francisco
(415) 476-3136

Education and Training

  • 1993-1997 National Taiwan University, Taipei, Taiwan
  • 2001-2004 M.S., Biomedical Engineering. University of California, Los Angeles
  • 2004-2007 Ph.D. Candidate, Biomedical Engineering. University of California, Los Angeles

Research experience

  • 2001-2007 University of California, Los Angeles - Dr. Desmond J. Smith, M.D., Ph.D.

Research interest

Key words: Multiple Sclerosis, Microarrays

Longitudinal genome-wide transcriptional profiles will be generated from peripheral blood cells in 500 MS patients and 100 well-matched controls. Samples taken at baseline, t1 (12 months) and t2 (24 months) will be used to characterize the temporal MS transcriptional activity over a 2-year period. All profiles will be generated using the Affymetrix Exon 1.0 ST arrays, thus interrogating over 1 million exons genome-wide. Using this platform, we will be able to generate both transcript- and exon-level expression profiles, providing an unprecedented level of resolution in the analysis of gene activity patterns in MS. An extensive quality control protocol will be implemented to monitor the integrity of the results at each stage of the process. 

Other

Recent Publications
Chen HP, Lin A, Bloom JS, Khan AH, Park CC, Smith DJ. Screening reveals conserved and nonconserved transcriptional regulatory elements including an E3/E4 allele-dependent APOE coding region enhancer. Genomics. Nov;92(5):292-300, 2008.